论文：
111. Li, H.; Ji, P.; Cao, Y.; Cui, Z.; Gao, J.; Wang, H.; Lin, C.; Wang, Y.; Wang, X.* (2024) Dimethylsulfoniopropionate (DMSP) increases longevity and mitochondrial function in Caenorhabditis elegans: implications for the role of the global sulfur cycle in terrestrial ecosystems. Environ, Health., DOI: 10.1021/envhealth.3c00208
110. Qin, X.#; Li, H.#; Zhao, H.*; Fang, L.*; Wang, X.* (2024) Enhancing healthy aging with small molecules: a mitochondrial perspective. Med. Res. Rev., DOI: 10.1002/med.22034 (#These authors contributed equally to this work)
109. Wang, K.; Wang, H.*; Wang, X.* (2024) The next-generation of vaccines for substance use disorders. Zool. Res., DOI: 10.24272/j.issn.2095-8137.2023.407
108. Zhang, C.; Wu, S.; Li, M.; Li, P.; Du, X.; Wang, Y.*; Wang, X.* (2024) Dissecting the chiral recognition of TLR4/MD2 with Neoseptin-3 enantiomers by molecular dynamics simulations. Phys. Chem. Chem. Phys., DOI: 10.1039/d3cp06124h
107. Gao, J.; Lin, C.; Zhang, C.; Zhang, X.; Xu, H.; Zhang, T.; Wang, Y.; Li, H.; Wang, H.*; Wang, X.* (2024) Exploring the function of (+)-naltrexone precursors: their activity as TLR4 antagonists and potential in treating morphine addiction. J. Med. Chem., 67, 3127–3143
106. Li, H.; Watkins, L.R.; Wang, X.* (2024) Microglia in neuroimmunopharmacology and drug addiction. Mol. Psychiatr., DOI: 10.1038/s41380-024-02443-6
105. Wang, Y.; Ngo, V.A.; Wang, X.* (2024) Stereoselective recognition of morphine enantiomers by μ-opioid receptor. Natl. Sci. Rev., 11(3), nwae029
104. Ming, A.#; Zhao, J.#; Liu, Y.; Wang, Y.; Wang, X.*; Li, J.*; Zhang, L.* (2024) O-glycosylation in viruses: a sweet tango. mLife, Doi: 10.1002/mlf2.12105 (#These authors contributed equally to this work)
103. Lin, C.; Wang, X.* (2023) Microglia in drug addiction: a perspective from neuroimmunopharmacology. Zool. Res., Doi: 10.24272/j.issn.2095-8137.2023.286
102. Shang, P.#; Rong, N.#; Jiang, J.#; Cheng, J.#; Zhang, M.#; Kang, D.#; Qi, L.#; Guo, L.; Yang, G.; Liu, Q.; Zhou, Z.; Li, X.; Zhu, K.; Meng, Q.; Han, X.; Yan, W.; Kong, Y.; Yang, L.; Wang, X.; Lei, D.; Feng, X.; Liu, X.; Yu, X.; Wang, Y.*; Li, Q.*; Shao, Z.*; Yang, F.*; Sun, J.* (2023) Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186(24), 5347-5362
101. Xu, Z.#; Guo, L.#; Yu, J.#; Shen, S.#; Wu, C.#; Zhang, W.#; Zhao, C.#; Deng, Y.; Tian, X.; Feng, Y.; Hou, H.; Su, L.; Wang, H.; Guo, S.; Wang, H.; Wang, K.; Chen, P.; Zhao, J.; Zhang, X.; Yong, X.; Cheng, L.; Liu, L.; Yang, S.; Yang, F.; Wang, X.; Yu, X.*; Xu, Y.*; Sun, J.*; Yan, W.*; Shao, Z.* (2023) Ligand recognition and G protein coupling of trace amine receptor TAAR1. Nature, 624, 672–681 (#These authors contributed equally to this work)
100. Zhang, X.#; Li, R.#; Xu, H.; Wu, G.; Wu, S.; Wang, H.; Wang, Y.*; Wang, X.* (2023) Dissecting the innate immune recognition of morphine and its metabolites by TLR4/MD2: an in silico simulation study. Phys. Chem. Chem. Phys., 25, 29656-29663
99. Jin, S.; Lin, C.; Wang, Y.; Wang, H.; Wen, X.; Xiao, P.; Li, X.; Peng, Y.; Sun, J.; Lu, Y.*; Wang, X.* (2023) Cannabidiol analogue CIAC001 for the treatment of morphine-induced addiction by targeting PKM2. J. Med. Chem., 66, 11498–11516
98. Zhang, J.; Lin, C.; Jin, S.; Wang, H.; Wang, Y.; Du, X.; Hutchinson M. R.; Zhao H.*; Fang, L.*; Wang, X.* (2023) The pharmacology and therapeutic role of cannabidiol in diabetes. Exploration, Doi: 10.1002/EXP.20230047
97. Wang, X.#; Lin, C.#; Jin, S.; Wang, Y.; Peng, Y.*; Wang, X.* (2023) Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5. Brain Behav. Immun., 111, 365-375 (#These authors contributed equally to this work)
96. Li, J.#; Yi, X.#; Liu, L.*; Wang, X.*; Ai, J.* (2023) Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death. Apoptosis, 28, 1198–1215 (#These authors contributed equally to this work)
95. Wu, S.; Zhang, C.; Wang, Y.; Li, P.; Du, X.; Wang, X.* (2023) Dissecting the species-specific recognition of Neoseptin 3 by TLR4/MD2 via molecular dynamics simulations. Phys. Chem. Chem. Phys., 25, 13012-13018
94. Li, M.#; Li, J.#; Wang, Y.#; Zhao, J.; Yuan, A.; Dong, W.; Kong, L.; Dong, S.; Qin, W.; Yang, Y.; Wang, X.*; Wu, C.*; Li, J.* (2023) DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing m6A binding. Fundam. Res., Doi: 10.1016/j.fmre.2023.04.017 (#These authors contributed equally to this work)
93. Li, J.#; Ahmad, M.#; Sang, L.#; Zhan Y.#; Wang, Y.; Yan, Y.; Liu, Y.; Mi, W.; Lu, M.; Dai, Y.; Zhang, R.; Dong, M.; Yang, Y.; Wang, X.*; Sun, J.*; Li, J.* (2023) O-GlcNAcylation promotes the cytosolic localization of the m6A reader YTHDF1 and colorectal cancer tumorigenesis. J. Biol. Chem., 299, 104738 (#These authors contributed equally to this work)
92. Wang, Y.; Wang, X.* (2023) Where to next in the evolution of in silico design of modulators targeting protein-protein interactions? Expert. Opin. Drug Discov.,18, 491-493
91. Kornilov, F.D.#; Shabalkina, A.V.#; Lin, C.#; Volynsky, P.E.; Kot, E.F.; Kayushin, A.L.; Lushpa, V.A.; Goncharuk, M.V.; Arseniev, A.S.; Goncharuk, S.A.*; Wang, X.*; Mineev, K.S.* (2023) The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors. Nat. Commun., 14, 1503 (#These authors contributed equally to this work)
90. Jiang, J.#; Wen, L.#; Wang, H.; Chen, X.*; Zhao, Y.*; Wang, X.* (2023) Detection and identification of amphetamine-type stimulants and analogs via recognition-enabled “chromatographic” 19F NMR. J. Fluor. Chem., 266, 110085 (#These authors contributed equally to this work)
89. Wang, F.#; Jin, T.#; Li, H.#;Long, H.; Liu, Y.; Jin, S.; Lu, Y.; Peng, Y.; Liu, C.; Zhao, L.*; Wang, X.* (2023) Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in caenorhabditis elegans. FASEB J., 37, e22735 (#These authors contributed equally to this work)
88. Li, Y.; Wang, Y.; Lu, L.; Shi, J.*; Wang, X.* (2022) Non-small molecule therapeutics for drug addiction: from pharmacokinetics modulating to synthetic biology. Fundam. Res., Doi:10.1016/j.fmre.2022.09.027
87. Wang, X.; Lin, C.*; Wu, S.; Zhang, T.; Wang, Y.; Jiang, Y.*; Wang, X.* (2022) Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia. Front. Immunol., 13, 929222
86. Wang, Y.; Zhang, C.; Tang, K.*; Wang, X.* (2022) En route for molecular dynamics simulation of a living cell. Fundam. Res., Doi:10.1016/j.fmre.2022.06.002
85. Zhang, T.; Lin, C.*; Wu, S.; Jin, S.; Li, X.; Peng, Y.*; Wang, X.* (2022) ACT001 inhibits TLR4 signaling by targeting co-receptor MD2 and attenuates neuropathic pain. Front. Immunol., 13, 873054
84. Wang, Q.#; Li, H.#; Zhang, G.; Chen, X.*; Wang, X.* (2022) Itaconate prolongs the healthy lifespan by activating UPRmt in Caenorhabditis elegans. Eur. J. Pharmacol. (#These authors contributed equally to this work)
83. Mustafa, S.*; Evans, S.; Barry, B.; Barratt, D.; Wang, Y.; Lin, C.; Wang, X.; Hutchinson M. R.; (2022) “Toll-like receptor 4 in pain: bridging molecules-to-cells-to-systems” Handbook of Experimental Pharmacology, 276, 239-273
82. Zhang, B.; Peng, Y.; Wang, Y.*; Wang, X.* (2022) Exploring the trimerization process of a transmembrane helix with an ionizable residue by molecular dynamics simulations: a case study of transmembrane domain 5 of latent LMP-1. Phys. Chem. Chem. Phys., 24, 7084-7092
81. Zhang, Y.#; Li, H.#; Jin, S.; Lu, Y.; Peng, Y.; Zhao, L.*; Wang, X.* (2022) Cannabidiol protects against Alzheimer’s disease in C.elegans via ROS scavenging activity of its phenolic hydroxyl groups. Eur. J. Pharmacol., 919, 174829 (#These authors contributed equally to this work)
80. Wu, S.; Lin, C.*; Zhang, T.; Zhang, B.; Jin, Y.; Wang, H.; Li, H.; Wang, Y.; Wang, X.* (2022) Pentamidine alleviates inflammation and lipopolysaccharide-induced sepsis by inhibiting TLR4 activation via targeting MD2. Front. Pharmacol., 13, 835081
79. Ji, P.#; Li, H.#; Jin, Y.; Peng, Y.; Zhao, L.*; Wang, X.* (2022) C. elegans as an in vivo model system for the phenotypic drug discovery for treating paraquat poisoning. PeerJ, 10, e12866 (#These authors contributed equally to this work)
78. Zhang, B.; Jin, Y.; Zhang, L.; Wang, H.*; Wang, X.* (2022) Pentamidine ninety years on: the development and applications of pentamidine and its analogs. Curr. Med. Chem., 29, 4602-4609
77. Wang, Y.; Wu, S.; Zhang, C.; Jin, Y.; Wang, X.* (2022) Dissecting the role of N-glycan at N413 in Toll-like receptor 3 via molecular dynamics simulations. J. Chem. Inf. Model., 62, 5258-5266
76. Zhang, Y.; Wang, X.; Xu, Y.; Liu, W.; Zhao, L. (2021) Preparation of graphene nano-drug carrier system and its killing effect on tumor cells. Chin. J. of Appl. Chem., 38, 693-703.
75. Yang, M.; Wang, X.; Pu, F.; Liu, Y.; Guo, J.; Chang, S.; Sun, G.*; Peng, Y.* (2021) Engineered exosomes-based photothermal therapy with MRI/CT imaging guidance enhances anticancer efficacy through deep tumor nucleus penetration. Pharmaceutics, 13, 1593
74. Yen, K. P.; Stanslas, J.; Zhang, T.; Li, H.; Wang, X.; Meng, C. K.; Wai, L. K.* (2021) Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines. Bioorg. Med. Chem., 49, 116442
73. Lushpa, V. A.; Goncharuk, M. V.; Lin, C.; Zalevsky, A. O.; Talyzina, I. A.; Luginina, A. P.; Vakhrameev, D. D.; Shevtsov, M. B.; Goncharuk, S. A.; Arseniev, A. S.; Borshchevskiy, V. I.; Wang, X.; Mineev, K. S.* (2021) Modulation of toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions. Commun. Biol., 4, 1003
72. Lu, X.#; Zhang, Y.#; Li, H.; Jin, S.; Zhao, L.*; Wang, X.* (2021) Nicotine prevents in vivo Aβ toxicity in Caenorhabditis elegans via SKN-1. Neurosci. Lett., 761, 136114 (#These authors contributed equally to this work)
71. Wang, S.#; Wang, H.#; Lin, C.; Zhang, T.; Gao, J.; Wu, S.; Wang, Y.; Li, H.; Min, W.; Liu, C.*; Wang, X.* (2021) Structure-activity relationship study of dihydroartemisinin C-10 hemiacetal derivatives as Toll-like receptor 4 antagonists. Bioorg. Chem., 114, 105107 (#These authors contributed equally to this work)
70. Lin, C.; Wang, H.; Zhang, M.; Mustafa, S.; Wang, Y.; Li, H.; Yin, H.; Hutchinson M. R.*; Wang, X.* (2021) TLR4 biased small molecule modulators. Pharmacol. Ther., 228, 107918
69. Zhang, B.; Zhang, L.*; Wang, H.; Wang, X.* (2021) Lessons learned from the explosion that occurred during the synthesis of diaminomethanesulfonic acid: discussion and preventative strategies. ACS Chem. Health Saf., 28, 244-249
68. Zhang, X.; Wang, H.*; Wang, Y.; Li, H.; Wu, S.; Gao, J.; Zhang, T.; Xie, J.*; Wang, X.* (2021) Nalmefene non-enantioselectively targets myeloid differentiation protein 2 and inhibits Toll-like receptor 4 signaling: wet-lab techniques and in silico simulations. Phys. Chem. Chem. Phys., 23, 12260-12269
67. Wang, F.#; Li, M.#; Lin, C.; Jin, S.; Li, H.; Lu, Y.; Wang, H.*; Wang, H.*; Wang, X.* (2021) Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity. Bioorg. Med. Chem., 39, 116131 (#These authors contributed equally to this work)
66. Wang, Z.#; Niu, J.#; Zhao, C.*; Wang, X.*; Ren, J.; Qu, X.*; (2021) A bimetallic metal-organic framework encapsulated with DNAzyme for intracellular drug synthesis and self-sufficient gene therapy. Angew. Chem. Int. Edit., 60, 12431-12437 (#These authors contributed equally to this work)
65. Wang, H.#; Dawber R. S.#; Zhang, P.#; Walko M.; Wilson, A. J.*; Wang, X.* (2021) Peptide-based inhibitors of protein-protein interaction: biophysical, structural and cellular consequences of introducing a constraint. Chem. Sci., 12, 5977-5993 (#These authors contributed equally to this work)
64. Wang, Y.#; Zhang, B.#; Lin, C.; Liu, Y.; Yang, M.; Peng, Y.*; Wang, X.* (2021) Dissecting role of charged residue from transmembrane domain 5 of latent membrane protein 1 via in silico simulations and wet-lab experiments. J. Phys. Chem. B., 125, 2124–2133 (#These authors contributed equally to this work)
63. Li, H.#; Peng, Y.#; Lin, C.; Zhang, X.; Zhang, T.; Wang, Y.; Li, Y.; Wu, S.; Wang, H.; Hutchinson M. R.; Watkins L. R.; Wang, X.* (2021) Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling. The Innovation., 2, 100111 (#These authors contributed equally to this work)
62. Zhang, B.; Wang, Y.; Lin, C.; Li, H.; Wang, X.; Peng, Y.; Mineev, K. S.; Wilson, A. J.; Wang, H.*; Wang, X.* (2021) Targeting the transmembrane domain 5 of latent membrane protein 1 using small molecule modulators. Eur. J. Med. Chem., 214, 113210
61. Zhang, T.; Zhang, X.; Lin, C.; Wu, S.; Wang, F.; Wang, H.; Wang, Y.; Peng, Y.; Hutchinson M. R.; Li, H.*; Wang, X.* (2021) Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood barrier leakage in mice. J. Neurochem., 157, 611-623
60. Liu, Y.; Li, H.; Li, Y.; Yang, M.; Wang, X.*.; Peng, Y.*; (2021) Velvet antler methanol extracts ameliorate Parkinson’s disease by inhibiting oxidative stress and neuroinflammation: from C.elegans to mice. Oxidative Med. Cell. Longev., 2021, 8864395
59. Peng, Y.#; Wang, Y.#; Wang, X.* (2020) Exploring the thermodynamics of 7-amino actinomycin D induced single-stranded DNA hairpin by spectroscopic techniques and computational simulations. J. Phys. Chem. B., 124, 10007–10013 (#These authors contributed equally to this work)
58. Kwilasz, A. J.; Todd, L. S.; Duran-Malle, J. C.; Schrama, A.E.W.; Mitten, E. H.; Larson, T. A.; Clements, M. A.; Harris, K. M.; Litwiler. S. T.; Wang X.; Dam, AM. V.; Maier, S. F.; Rice, K. C.; Watkins, L. R.; Barrientos, R. M.* (2020) Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone. Behav. Brain Res., 396, 112896
57. Kot, E. F.#; Wang, Y.#; Goncharuk, S. A.; Zhang, B.; Arseniev, A. S.; Wang, X.*; Mineev, K. S.*; (2020) Oligomerization analysis as a tool to elucidate the mechanism of EBV latent membrane protein 1 inhibition by pentamidine. Biochim. Biophys. Acta-Biomembr.,1862, 183380 (#These authors contributed equally to this work)
56. Lu, M.; Li, H.; Li, Y.; Lu, Y.; Wang, H.*.; Wang, X.* (2020) Exploring the Toxicology of Depleted Uranium with Caenorhabditis elegans. ACS Omega., 5, 12119–12125
55. Yan, L.; Liang, J.; Zhou, Y.; Huang, J.; Zhang, T.; Wang X.; Yin, H.* (2020) Switch off “Parallel Circuit”: insight of new strategy of simultaneously suppressing canonical and noncanonical inflammation activation in endotoxemic mice. Adv Biosyst., 4, e2000037
54. Wang, Y.; Zhang, S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson M. R.; Yin, H.*; Wang, X.* (2020) Small-molecule modulators of Toll-like receptors. Acc. Chem. Res., 53, 1046-1055
53. Zhang, X.; Wang, Y.; Wang, H.; Li, H.; Zhang, T.; Peng, Y.; Wang, X.* (2020) Exploring methamphetamine nonenantioselectively targeting Toll-like receptor 4/Myeloid Differentiation Protein 2 by in silico simulations and wet-lab techniques. J. Chem. Inf. Model., 60, 1607-1613
52. Yang, M.#; Liu, Y.#; Wang, M.; Yang, C.; Sun, S.; Zhang, Q.; Guo, J.; Wang, X.*; Sun, G.*; Peng, Y.* (2019) Biomineralized Gd/Dy composite nanoparticles for enhanced tumor photoablation with precise T1/T2-MR/CT/ thermal imaging guidance. Chem. Eng. J., 391, 123562 (#These authors contributed equally to this work)
51. Wang, X.#; Li, H.#; Liu, Y.; Wu, H; Wang, H.; Jin, S.; Lu, Y.; Chang, S.; Liu, R.; Peng, Y.*; Guo, Z.*; Wang, X.* (2019) Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1. Biomed. Pharmacother., 121, 109668 (#These authors contributed equally to this work)
50. Peng, Y.#; Zhang, X.#; Zhang, T.; Grace, P.; Li, H.; Wang, Y.; Chen, H.; Watkins L. R.; Hutchinson M. R.; Yin H.; Wang, X.* (2019) Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain Behav. Immun., 82, 432-444 (#These authors contributed equally to this work)
49. Wang, X.*; Northcutt, A. L.; Cochran, T. A.; Zhang, X.; Fabisiak, T. J.; Haas, M. E.; Amat, J.; Li, H.; Rice, K. C.; Maier, S. F; Bachtell, R. K.; Hutchinson, M. R.; Watkins, L. R. (2019) Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. ACS Chem. Neurosci., 10, 3622-3634
48. Wang, Y.#; Peng, Y.#; Zhang, B.; Zhang, X.; Li, H.; Wilson, A. J.; Mineev, K. S.; Wang, X.* (2019) Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide. Chem. Sci., 10, 7584-7590 (#These authors contributed equally to this work)
47. Zhang, X.#; Peng, Y.#; Grace, P. M.; Metcalf, M. D.; Kwilasz, A. J.; Wang, Y.; Zhang, T.; Wu, S.; Selfridge, B. R.; Portoghese, P. S.; Rice, K. C.; Watkins, L. R.; Hutchinson, M. R.; Wang, X.* (2019) Stereochemistry and innate immune recognition: (+)-Norbinaltorphimine enantioselectively targets myeloid differentiation protein 2 and inhibits Toll-like receptor 4 signaling. FASEB J., 33, 9577-9587 (#These authors contributed equally to this work)
46. Li, Y.; Li, H.; Zhao, L.*; Wang, X.* (2019) Effect of anti-oxidant property of short branched-chain fatty acids in Caenorhabditis elegans. Chin. J. Biochem. Mol. Biol., 35, 404-412
45. Li, H.; Wang, K.; Yao, J.; Liu, Z.; Zhou, H.; Wang, X.* (2019) Research progress in the development of nicotine as a medicine. Prog. Pharm. Sci., 43, 824-831
44. Du, Z; Gao, N.*; Wang, X, Ren, J.; Qu, X.* (2018) Near-Infrared switchable fullerene-based synergy therapy for Alzheimer’s disease. Small, 14, 1801852
43. Peng, Y.; Wang, X.* (2018) Kineret protein solution survives ten years. J. Pharm. Biomed. Anal., 160, 383-385
42. Zhang, X.; Cui, F.*; Chen, H.; Zhang, T.; Wang, Y.; Jiang, Z.; Yang, K.; Rice, K. C.; Linda, L. R.; Hutchinson, M. R.; Li, Y.; Peng, Y. and Wang, X.* (2018) Dissecting the innate immune recognition of opioid inactive isomer (+)-naltrexone derived Toll-like receptor 4 (TLR4) antagonists. J. Chem. Inf. Model., 58, 816-825
41. Grace, P. M.#*; Wang, X.#; Strand, K. A.; Baratta, M. V.#; Zhang, Y.; Galer, E. L.; Yin, H.; Maier S. F.; Watkins, L. R. (2018) DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Exp. Neurol., 304, 125-131 (#These authors contributed equally to this work)
40. Guan, Y.; Du, Z.; Gao, N.*; Cao, Y.; Wang, X.; Scott, P.; Song, H.; Ren, J.; Qu, X.* (2018) Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide. Sci. Adv., 4, eaao6718
39. Zhang, X.; Zhang, T.; Cui, F.; Li Y.; Peng Y.; Wang, X.* (2016) Small molecule modulators of Toll-like receptor 4. Chin. J. of Appl. Chem., 33, 876-886
38. Grace, P. M.*; Strand, K. A.; Galer, E. L.; Urban, D. J.; Wang, X.; Baratta, M. V.; Fabisiak, T. J.; Anderson, M. D.; Chen, K.; Greene, L. I.; Berkelhammer D.; Zhang, Y.; Ellis, E. L.; Yin, H.; Campeau, S.; Rice, K. C.; Roth, B. L.; Maier, S. F.; Watkins, L. R. (2016) Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc. Natl. Acad. Sci. U.S.A., 113, E3441-E3450
37. Zhang, T.#; Peng, Y.#; Wang, X.*. (2016) Drug discovery for treating drug addiction by targeting glia. Prog. Pharm. Sci., 39, 56-61 (#These authors contributed equally to this work)
36. Wang, X.*; Zhang, Y.; Peng, Y.; Hutchinson, M. R.; Rice, K. C.; Yin, H.; Watkins, L. R. (2016) Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. Br. J. Pharmacol., 173, 856-869
35. Selfridge, B. R.#; Wang, X.#; Zhang, Y.; Yin, H.; Watkins, L. R.; Jacobson, A. E.; Rice, K. C.* (2015) Structure-activity relationships of (+)-naltrexone-inspired Toll-like receptor 4 (TLR4) antagonists. J. Med. Chem., 58, 5038–5052 (#These authors contributed equally to this work)
34. Grace, P. M.; Wang, X.; Urban, D.; Baratta, M.; Galer, E.; Strand, K.; Zhang, Y.; Yin, H.; Roth, B.; Maier, S.; Watkins, L. R.* (2015) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling. J. Pain, 16, S38
33. Smith, C.#; Wang, X.#; Yin, H.* (2015) Caspases come together over LPS. Trends Immunol., 36, 59-61 (#These authors contributed equally to this work)
32. Wang, X.; Wang, X.; Feng, Y.; Zhu, M.; Yin, H.; Guo, Q.; Meng, X.* (2015) A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells. Dalton Trans., 44, 6613-6619
31. Yang, H.#; Chen, Y. Z.#; Zhang, Y.#; Wang, X.; Zhao, X.; Godfroy, J. I.; Lian, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D.* (2015) A Lysin-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat. Commun., 6, 5717 (# These authors contributed equally to this work)
30. Bachtell, R.*; Hutchinson, M. R.; Wang, X.; Rice, K. C.; Maier, S. F.; Watkins, L. R. (2015) Targeting the Toll of drug abuse: the translational potential of Toll-like receptor 4. CNS Neurol. Disord. Drug Targets, 14, 692-699
29. Northcutt, A. L.*; Hutchinson, M. R.#; Wang, X.#; Baratta, M.; Hiranita, T.; Cochran, T.; Pomrenze, M.; Galer, E.; Kopajtic, R.; Li, C. M.; Amat, J.; Larson, G.; Cooper, D.; Huang, Y.; O’Neil, C.; Yin, H.; Zahniser, N.; Katz, J.; Rice, K. C.; Maier, S. F.; Bachtell, R.; Watkins, L. R. (2015) DAT isn’t all that: cocaine reward and reinforcement requires Toll like receptor 4 signaling. Mol. Psychiatr., 20, 1525-1537 (#These authors contributed equally to this work)
28. Grace, P. M.*; Ramos, K. M.; Rodgers, K. M.; Wang, X.; Hutchinson, M. R.; Lewis M. T.; Morgan, K. N.; Kroll, J. L.; Taylor, F. R.; Strand, K. A.; Zhang, Y.; Berkelhammer, D.; Huey, M.; Greene, L. I.; Cochran, T. A.; Yin, H.; Barth, D. S.; Johnson, K. W.; Rice, K.; Maier, S. F.; Watkins, L. R. (2014) Activation of adult rat CNS endothelial cells by opioid-induced TLR4 signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience, 280, 299-317
27. Wang, X.; Cochran, T. A.; Hutchinson, M. R.; Yin, H.; Watkins, L. R.* (2014) “Drug addiction” in Microglia in health and disease (Sierra, A.; Tremblay, M. E. Ed.), Springer-Verlag (Berlin Heidelberg), 299-317
26. Watkins, L. R.*; Wang, X.; Mustafa, S.; Hutchinson, M. R. (2014) In vivo veritas:(+)-naltrexone’s actions define translational importance. Trends Pharmacol. Sci., 35, 432-433
25. Wang, X., Smith, C.; Yin, H.* (2013) Targeting Toll-like receptors with small molecule agents. Chem. Soc. Rev., 42, 4859-4866
24. Wang, X.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C.; Li, J.; Watkins, L. R.; Yin, H.* (2013) Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. FASEB J., 27, 2713-2722
23. Li, J.#; Wang, X.#; Zhang, F.; Yin, H.* (2013) Toll-like receptors as the therapeutic targets of autoimmune connective tissue diseases. Pharmacol. Ther., 138, 441-451 (#These authors contributed equally to this work)
22. Wang, X.; Saludes, J. P.; Zhao, T. X.; Csakai, A.; Fiorini, Z.; Chavez, S. A.; Li, J.; Lee, G. I.; Varga, K.; Yin, H.* (2012) Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein 1. Biochim. Biophys. Acta-Biomembranes, 1818, 2282-2289
21. Wang, X.; Fiorini, Z.; Smith T.; Zhang, Y.; Li, J.*; Watkins, L. R.; Yin, H.* (2012) Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. PLoS One, 7, e47703
20. Wang, X.; Loram, L. C.; Ramos, K.; de Jesus, A. J.; Jacob, A. J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; Yin, H.* (2012) Morphine activates neuroinflammation in a parallel manner to endotoxin. Proc. Natl. Acad. Sci. U.S.A., 109, 6325-6330
19. Cheng, K.; Wang, X.; Zhang, S.; Yin, H.* (2012) Discovery of small-molecule inhibitors of the TLR1-TLR2 complex. Angew. Chem. Int. Edit., 51, 12246-12249
18. Zhang, S.; Cheng, K.; Wang, X.; Yin, H.* (2012) Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitor. Bioorg. Med. Chem., 20, 6073-6079
17. Hutchinson, M. R.#; Northcutt, A. L.#; Hiranita, T.; Wang, X.; Lewis, S.; Kopajtic, T. A.; Loram, L.; Sfregola, C.; Galer, E.; Miles, N. E.; Bland, S. T.; Amat, J.; Rozeske, R. R.; Maslanik, T.; Chapman, T.; Strand, K.; Fleshner, M.; Bachtell, R. K.; Yin, H. J.; Katz, L.; Rice, K. C.; Maier, S. F.; Watkins, L. R.* (2012) Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement. J. Neurosci., 32, 11187-11200 (#These authors contributed equally to this work)
16. Cheng, K.; Wang, X.; Yin, H.* (2011) Small molecule inhibitors of the TLR3/dsRNA complex. J. Am. Chem. Soc., 133, 3764-3767
15. Wang, X.; Qu, K.; Xu, B.; Ren, J.; Qu, X.* (2011) Microwave assisted one-step green synthesis of multicolor photoluminescent carbon dots without surface passivation reagents. J. Mater. Chem., 21, 2445-2450
14. Wang, X.; Qu, K.; Xu, B.; Ren, J.; Qu, X.* (2011) Multicolor luminescent carbon nanoparticles: synthesis, supramolecular assembly with porphyrin, intrinsic peroxidase-like catalytic activity and application. Nano Res., 4, 908-920
13. Wang, X.; Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X.* (2011) Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe. Biosens. Bioelectron., 26, 4804-4809
12. Wang, X.; Chen, Y.; Ren, J.; Qu, X. (2011) Small interfering RNA for effective cancer therapies. Mini. Rev. Med. Chem., 11, 114-124
11. Song, Y.; Wang, X.; Zhao, C.; Qu, K.; Ren, J.; Qu, X.* (2010) Label-free colorimetric detection of single nucleotide polymorphism by using single-walled carbon nanotube intrinsic peroxidase-like activity. Chem. Eur. J., 16, 3617-3621
10. Wang, X.; Geng, J.; Miyoshi, D.; Ren, J.; Sugimoto, N.; Qu, X.* (2010) A rapid and sensitive “add-mix-measure” assay for multiple proteinases based on one gold nanoparticle–peptide–fluorophore conjugate. Biosens. Bioelectron., 26, 743-747
9. Wang, X.; Wang, C.; Qu, K.; Song, Y.; Ren, J.; Miyoshi, D.; Sugimoto, N.*; Qu, X.* (2010). Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes. Adv. Funct. Mater., 20, 3967-3971
8. Peng, Y.; Wang, X.; Xiao, Y.; Feng, L.; Zhao, C.; Ren. J.; Qu, X.* (2009) An i-motif quadruplex DNA-based biosensor for distinguishing single- and multi-walled carbon nanotubes. J. Am. Chem. Soc., 131, 13813-13818
7. Wang, X.; Song, Y.; Ren, J.; Qu, X.* (2009) Knocking-down cyclin A2 by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin. PLoS One, 4, e6665
6. Yu, H.; Wang, X.; Fu, M.; Ren, J.; Qu, X.* (2008) Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA. Nucleic Acids Res., 36, 5695-5703
5. Shi, Q.; Wang, X.; Ren, J.* (2008) Biophysical characterization of the interaction of p21 with calmodulin: a mechanistic study. Biophys. Chem., 138, 138-143
4. Wang, X.; Ren, J.; Qu, X.* (2008) Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells. ChemMedChem, 3, 940-945
3. Wang, X.; Ren, J.; Qu, X.* (2008) Biophysical studies on the full-length human cyclin A2: protein stability and folding/unfolding thermodynamics. J. Phys. Chem. B, 112, 8346-8353
2. Bao, H.; Wang, X.; Yu, H.; Fu, M.; Qu, X.*; Zheng, Y.; Ren, J. (2007) Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs. Chem. Phys. Lett., 436, 252-257
1. Wang, X.; Fu, M.; Ren, J.; Qu, X.* (2007) Evaluation of different culture conditions for high-level soluble expression of human cyclin A2 with pET vector in BL21 (DE3) and spectroscopic characterization of its inclusion body structure. Protein Expr. Purif., 56, 27-34