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42. Zhang X.; Cui, F. * ; Chen, H.; Zhang, T.; Wang, Y.; Jiang, Z.; Yang, K.; Rice, K.C.; Linda, L.R.; Hutchinson, M.R.; Li, Y.; Peng, Y. and Wang, X. *(2018) Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. J. Chem. Inf. Model, 58 (4), 816-825

41.Grace, P. M.#; Wang, X.#; Strand, K. A.; Baratta, M.V.; Zhang, Y.; Galer, E. L.; Yin, H.; Maier S. F.; Watkins,  L. R. (2018)DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.Exp Neurol., 304, 125-131.(#These authors contribute equally to this work)

40. Guan Y.; Du Z.; Gao N.; Cao Y.; Wang X.; Scott P.; Song H.; Ren J.; Qu X. (2018)Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide, Sci Adv.,4, eaao6718.

39. Zhang, X.; Zhang, T.; Cui, F.; Li Y.; Peng Y.; Wang X.*(2016) Small molecule modulators of Toll-like receptor 4, Chin. J. of Appl. Chem., 33, 876-886.

38. Grace, P. M.; Strand, K. A.; Galer, E. L.; Urba, D. J.; Wang, X.; Baratta, M. V.; Fabisiak, T. J.; Anderson, M. D.; Chen, K.; Greene, L. I.; Berkelhammer D.; Zhang, Y.; Ellis, E. L.; Yin, H.; Campeau, S.; Rice, K. C.; Roth, B. L.; Maier, S. F.; Watkins, L.R. (2016) Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.Proc. Natl. Acad. Sci. USA, 113,E3441-E3450.

37. Zhang, T#.; Peng, Y.#; Wang, X*.(2016)Drug discovery for treating drug addiction by targeting glia,Prog.Pharm.Sci. 39,40, 56-61(#These authors contribute equally to this work; *Corresponding author; Invited review)

36.Wang, X.*; Zhang, Y.; Hutchinson, M. R.; Rice, K. C.; Yin, H.; Watkins, L. R. (2016) Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists.Br. J. Pharmacol.,173,856-869. (*Corresponding author)

35.Selfridge, B. R.#; Wang, X.#;Zhang, Y.; Yin, H.; Watkins, L. R.; Jacobson, A. E.; Rice, K. C. (2015)Structure activity relationships of (+)-naltrexone-inspired Toll-like receptor 4 (TLR4) antagonists. J. Med. Chem., 58,5038–5052. (#These authors contribute equally to this work)

34. Grace, P.; Wang, X.; Urban, D.; Baratta, M.; Galer, E.; Strand, K.; Zhang, Y.; Yin, H.; Roth, B.;  Maier, S.; Watkins, L. R.(2015)Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling. J. Pain, 4 , S38

33. Smith, C.#; Wang, X.#; Yin, H. (2015)Caspases come togetherover LPS.Trends Immunol., 36, 59-61. (#These authors contribute equally to this work)

32.Wang, X.; Wang, X.; Feng, Y.; Zhu, M.; Yin, H.; Guo, Q.; Meng, X. (2015)A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells.Dalton Trans., 44, 6613-6619.

31.Yang, H.#; Chen, Y. Z.#; Zhang, Y.#; Wang, X.;  Zhao, X.; Godfroy, J. I.; Lian, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D. (2015) A Lysin-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat. Commun., 6, 5717. (# These authors contribute equally to this work)

30.Bachtell, R.; Hutchinson, M. R.; Wang, X. ; Rice, K. C.; Maier, S. F,; Watkins, L. R. (2015) Targeting the Toll of drug abuse: the translational potential of  Toll-like receptor 4. CNS Neurol.Disord. Drug Targets., 14, 692-699.

29. Northcutt, A. L.#; Hutchinson, M. R.#; Wang, X.#; Baratta, M.; Hiranita, T.; Cochran, T.; Pomrenze, M.; Galer, E.; Kopajtic, R.; Li, C. M.; Amat, J.; Larson, G.; Cooper, D.; Huang, Y.; O'Neil, C.; Yin, H.; Zahniser, N.; Katz, J.; Rice, K. C.; Maier, S. F.; Bachtell, R.; Watkins, L.R. (2015)DAT isn't all that: cocaine reward and reinforcement requires Toll like receptor 4 signaling. Mol. Psychiatry, 20,1525-1537.(#These authors contribute equally to this work)

28.Grace, P. M.; Ramos, K. M.; Rodgers, K. M.; Wang, X.; Hutchinson, M. R.; Lewis M. T.; Morgan, K. N.; Kroll, J. L.; Taylor, F. R.; Strand, K. A.; Zhang, Y.; Berkelhammer, D.; Huey, M.; Greene, L. I.; Cochran, T. A.; Yin, H.; Barth, D. S.; Johnson, K. W.; Rice, K.; Maier, S. F.; Watkins, L. R. (2014) Activation of adult rat CNS endothelial cells by opioid-induced TLR4 signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae, Neuroscience, 280, 299-317.

27. Wang, X.;Cochran, T.A.; Hutchinson, M. R.; Yin, H.; Watkins, L. R.  (2014)  "Drug addiction" in Microglia in health and disease (Sierra, A.; Tremblay, M. E. Ed.), Springer-Verlag (Berlin Heidelberg), 299-317.

26. Watkins, L. R.;Wang, X.;Mustafa, S.;Hutchinson, M. R. (2014)  In vivo veritas:(+)-naltrexone's actions define translational importance, Trends Pharmacol.Sci.,35, 432-433

25. Wang, X., Smith, C.; Yin, H. (2013) Targeting Toll-like receptors with small molecule agents,Chem. Soc. Rev., 42, 4859-4866. (Cover article)

24. Wang, X.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C.; Li, J.; Watkins, L. R.; Yin, H. (2013)Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain, FASEB J., 27, 2713-2722

23. Li, J.#; Wang, X.#; Zhang, F.; Yin, H (2013) Toll-like receptors as the therapeutic targets of autoimmune connective tissue diseases, Pharmacol. Ther., 138, 441-45 (#These authors contribute equally to this work)

22. Wang, X.; Saludes, J. P.; Zhao, T. X.; Csakai, A.; Fiorini, Z.; Chavez, S. A.; Li, J.; Lee, G. I.; Varga, K.; Yin, H. (2012) Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein 1,Biochim. Biophys. Acta-Biomembranes, 1818, 2282-2289. (This research has been highlighted by NewsRx, the world's largest producer of health news.)

21. Wang, X.; Fiorini, Z.; Smith T.; Zhang, Y.; Li, J.; Watkins, L. R.; Yin, H. (2012)Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1,PLoS One, e47703

20.Wang, X.;Loram, L.C.; Ramos, K.; de Jesus, A. J.; Jacob, A. J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; Yin, H. (2012)Morphine activates neuroinflammataion in a parallel manner to endotoxin, Proc. Natl. Acad. Sci. USA, 109, 6325-6330. (This work has been highlighted by Nature, PNAS, Science Signaling (Editors' choice), Faculty of 1000, American Association of Universities, and several other media; One-line impact: Top 7% compared to articles of the same age)

19.Cheng, K.; Wang, X.; Zhang, S.;Yin, H. (2012) Discovery of small molecule inhibitors of the TLR1-TLR2 complex, Angew. Chem. Int. Edit.,51, 12246-12249. (Cover article, highlighted by C&EN)

18.Zhang, S.; Cheng, K.; Wang, X.; Yin, H.(2012)Selection, synthesis, and antiinflammatory evaluation of the arylidenemalonate derivatives as TLR4 signaling inhibitor, Bioorg. Med. Chem., 20, 6073-6079. (Cover article).

17. Hutchinson, M. R.; Northcutt, A. L.; Hiranita, T.; Wang, X.; Lewis, S.; Kopajtic, T. A.; Loram, L.; Sfregola, C.; Galer, E.; Miles, N. E.; Bland, S. T.; Amat,  J.; Rozeske, R. R.; Maslanik, T.; Chapman, T.; Strand, K.; Fleshner, M.; Bachtell, R. K.; Yin, H. J.; Katz, L.; Rice, K. C.; Maier, S. F.; Watkins, L. R.  (2012)Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement, J. Neurosci., 32, 11187-11200. (This work has been highlighted by Washington Post, Newscientistand several other media)

16.Cheng, K.; Wang, X.; Yin, H. (2011) Small molecule inhibitors of the TLR3/dsRNAcomplex,J. Am. Chem. Soc., 133, 3764-3767.

15. Wang, X.; Qu, K.; Xu, B.;  Ren, J.; Qu, X. (2011)Microwave assisted one-step green synthesis of multicolorphotoluminescentcarbondots without surface passivation reagents,J. Mater. Chem., 21, 2445-2450.(This paper has been cited more than 300 times)

14.Wang, X.; Qu, K.; Xu, B.; Ren, J.; Qu, X. (2011)Multicolor luminescent carbon nanoparticles: synthesis, supramolecularassembly with porphyrin, intrinsic peroxidase-like catalytic activity and application,Nano Res., 4, 908-920. (This research has been featured byLife Science Weekly)

13. Wang, X.; Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X. (2011) Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe,Biosens. Bioelectron., 26, 4804-4809.

12. Wang, X.;Chen, Y.;Ren, J.;Qu, X. (2011) Small interfering RNA for effective cancer therapies, Mini. Rev. Med. Chem., 11, 114-124.

11.Song, Y.;Wang, X.;  Zhao, C.;Qu, K.;Ren, J.;Qu, X. (2010) Label-free colorimetric detection of single nucleotide polymorphism by using single-walled carbon nanotube intrinsic peroxidase-like activity, Chem. Eur. J., 16, 3617-3621.

10. Wang, X.; Geng, J.;Miyoshib,D.;Ren, J.; Sugimoto, N.;Qu, X. (2010) A rapid and sensitive "add-mix-measure" assay for multiple proteinases based on one gold nanoparticle–peptide–fluorophore conjugate, Biosens. Bioelectron.,26, 743-747.

9.Wang, X.; Wang, C.; Qu, K.;Song, Y.;Ren, J.;Miyoshi, D.;Sugimoto, N.;Qu, X. (2010). Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes, Adv. Funct. Mater., 20, 3967-3971.(Inner cover article; This work has been highlighted byWILEY-VCH Materials Views China)

8. Peng, Y.;Wang, X.; Xiao, Y.;Feng, L.; Zhao, C.;Ren. J.; Qu, X. (2009) An i-motif quadruplex DNA-based biosensor for distinguishing single- and multi-walled carbon nanotubes, J. Am. Chem. Soc., 131, 13813-13818.

7. Wang, X.;Song, Y.;Ren, J.;Qu, X. (2009) Knocking-down cyclin A2 by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin, PLoS One, 4, e6665.

6.. Yu, H.;Wang, X.;Fu, M.;Ren, J.; Qu, X. (2008) Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 36, 5695-5703.

5. Shi, Q.;Wang, X.;Ren, J. (2008) Biophysical characterization of the interaction of p21 with calmodulin: a mechanistic study, Biophys. Chem., 138, 138-143.

4. Wang, X.;Ren, J.;Qu, X. (2008) Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenousleukemia K562 cells, ChemMedChem, 3, 940-945.(It is one of the most cited papers ChemMedChempublished in 2008/2009)

3. Wang, X.;Ren, J.;Qu, X. (2008) Biophysical studies on the full-length human cyclin A2: protein stability and folding/unfolding thermodynamics, J. Phys. Chem. B, 112, 8346-8353.

2.Bao, H.;Wang, X.;Yu, H.;Fu, M.;Qu, X.;Zheng, Y.;Ren, J. (2007) Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett.,436, 252-257.

1. Wang, X.;Fu, M.;Ren, J.;Qu, X. (2007) Evaluation of different culture conditions for high-level soluble expression of human cyclin A2 with pET vector in BL21 (DE3) and spectroscopic characterization of its inclusion body structure, Protein Expr. Purif., 56, 27-34.

发表著作:

Wang, X.; Cochran, T. A.; Hutchinson, M. R.; et al., Drug Addiction, in Microglia in Health and Disease, M.-È. Tremblay and A. Sierra, Editors. 2014, Springer New York: New York, NY. 299-317. (Chapter)