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发表论文:

  • Wang, X.*; Yin, H*. (2016) Small molecule modulators of Toll-like receptors, Acc. Chem. Res. (IF=22.323), 48, in preparation. (*Corresponding author; Invited review)
  • Zhang X.; Zhang T.; Cui F.; Li Y.; Peng Y.; Wang X.*. (2016) Toll-like Receptor 4 Small Molecule Modulators. Chin. J. Appl. Chem., 33, 876-886.(*Corresponding author; Invited review)
  • Zhang, T.; Peng, Y.#; Wang, X.*.(2016) Drug discovery for treating drug addiction by targeting glia, Prog. Pharm. Sci. 40, 56-61. (#These authors contribute equally to this work; *Corresponding author; Invited review)
  • Wang, X.*; Zhang, Y.; Hutchinson, M. R.; Rice, K. C.; Yin, H.; Watkins, L. R. (2016) Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. Br. J. Pharmacol. (IF=4.842), 173, 856-869.(*Corresponding author)
  • Selfridge, B. R. #Wang, X. #; Zhang, Y.; Yin, H.; Watkins, L. R.; Jacobson, A. E.; Rice, K. C. (2015) Structure activity relationships of (+)-naltrexone-inspired Toll-like receptor 4 (TLR4) antagonists. J. Med. Chem.IF=5.447, 58, 5038–5052.(#These authors contribute equally to this work)
  • Grace, P.; Wang, X.; Urban, D.; Baratta, M.; Galer, E.; Strand, K.; Zhang, Y.; Yin, H.; Roth, B.;  Maier, S.; Watkins, L. R. (2015) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling. J. PainIF=4.010, 4 , S38
  • Smith, C. #Wang, X.# ; Yin, H. (2015) Caspases come together over LPS. Trends Immunol.IF=10.399, 36, 59-61. (#These authors contribute equally to this work)
  • Wang, X.; Wang, X.; Feng, Y.; Zhu, M.; Yin, H.; Guo, Q.; Meng, X. (2015)A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells. Dalton Trans.IF=4.197, 44, 6613-6619.
  • Yang, H. #; Chen, Y. Z. #; Zhang, Y. #Wang, X.;  Zhao, X.; Godfroy, J. I.; Lian, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D. (2015) A Lysin-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat. Commun.IF=11.470, 6, 5717. (These authors contribute equally to this work)
  • Bachtell, R.; Hutchinson, M. R.; Wang, X. ; Rice, K. C.; Maier, S. F,; Watkins, L. R. (2015) Targeting the Toll of drug abuse: the translational potential of  Toll-like receptor 4. CNS Neurol.Disord. Drug Targets.IF=2.628, 14, 692-699.
  • Northcutt, A. L.; Hutchinson, M. R. #Wang, X.#; Baratta, M.; Hiranita, T.; Cochran, T.; Pomrenze, M.; Galer, E.; Kopajtic, R.; Li, C. M.; Amat, J.; Larson, G.; Cooper, D.; Huang, Y.; O'Neil, C.; Yin, H.; Zahniser, N.; Katz, J.; Rice, K. C.; Maier, S. F.; Bachtell, R.; Watkins, L.R. (2015) DAT isn't all that: cocaine reward and reinforcement requires Toll like receptor 4 signaling. Mol. Psychiatry (NPG)IF=14.496, 20, in press (DOI: 10.1038/mp.2014.177). (#These authors contribute equally to this work)
  • Grace, P. M.; Ramos, K. M.; Rodgers, K. M.; Wang, X.; Hutchinson, M. R.; Lewis M. T.; Morgan, K. N.; Kroll, J. L.; Taylor, F. R.; Strand, K. A.; Zhang, Y.; Berkelhammer, D.; Huey, M.; Greene, L. I.; Cochran, T. A.; Yin, H.; Barth, D. S.; Johnson, K. W.; Rice, K.; Maier, S. F.; Watkins, L. R. (2014) Activation of Adult Rat Cns Endothelial Cells by Opioid-Induced Toll-Like Receptor 4 (Tlr4) Signaling Induces Proinflammatory, Biochemical, Morphological, and Behavioral Sequelae, NeuroscienceIF=3.357, 280, 299-317.
  • Watkins, L. R.; Wang, X.; Mustafa, S.; Hutchinson, M. R. (2014)  In vivo veritas: (+)-naltrexone's actions define translational importance, Trends Pharmacol. Sci.IF=11.539, 35, 432-433.
  • Wang, X.; Smith, C.; Yin, H. (2013) Targeting Toll-like receptors with small molecule agents,Chem. Soc. Rev.IF=33.383,42, 4859-4866. (Cover article)
  • Wang, X.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C.; Li, J.; Watkins, L. R.; Yin, H. (2013) Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain, FASEB J.IF=5.043, 27, 2713-2722.
  • Li, J.#Wang, X.#; Zhang, F.; Yin, H (2013) Toll-like receptors as the therapeutic targets of autoimmune connective tissue diseases, Pharmacol. Ther.IF=9.723, 138, 441-45. (#These authors contribute equally to this work)
  • Wang, X.; Saludes, J. P.; Zhao, T. X.; Csakai, A.; Fiorini, Z.; Chavez, S. A.; Li, J.; Lee, G. I.; Varga, K.; Yin, H. (2012) Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein 1, Biochim. Biophys. Acta-BiomembranesIF=3.836, 1818, 2282-2289. (This research has been highlighted by NewsRx, the world's largest producer of health news.)
  • Wang, X.; Fiorini, Z.; Smith T.; Zhang, Y.; Li, J.; Watkins, L. R.; Yin, H. (2012) Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1, PLoS OneIF=3.234,10, e47703.
  • Wang, X.; Loram, L.C.; Ramos, K.; de Jesus, A. J.; Jacob, A. J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; Yin, H. (2012) Morphine activates neuroinflammataion in a parallel manner to endotoxin, Proc. Natl. Acad. Sci. USAIF=9.809, 109, 6325-6330. (This work has been highlighted by Nature, PNAS, Science Signaling (Editors' choice), Faculty of 1000, American Association of Universities, Science Daily, Colorado Daily and several other media; One-line impact: Top7% compared to articles of the same age)
  • Cheng, K.; Wang, X.; Zhang, S.; Yin, H. (2012) Discovery of small molecule inhibitors of the TLR1-TLR2 complex, Angew. Chem. Int. Edit.IF=11.262, 51, 12246-12249. (Cover article, highlighted by C&EN)
  • Zhang, S.; Cheng, K.; Wang, X.; Yin, H. (2012) Selection, synthesis, and anti-inflammatory evaluation of the aryliden emalonate derivatives as TLR4 signaling inhibitor, Bioorg. Med. Chem.IF=2.793, 20, 6073-6079. (Cover article).
  • Hutchinson, M. R.; Northcutt, A. L.; Hiranita, T.; Wang, X.; Lewis, S.; Kopajtic, T. A.; Loram, L.; Sfregola, C.; Galer, E.; Miles, N. E.; Bland, S. T.; Amat,  J.; Rozeske, R. R.; Maslanik, T.; Chapman, T.; Strand, K.; Fleshner, M.; Bachtell, R. K.; Yin, H. J.; Katz, L.; Rice, K. C.; Maier, S. F.; Watkins, L. R.  (2012) Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement, J. Neurosci.IF=6.344, 32, 11187-11200. (This work has been highlighted by Washington Post, Newscientist, Asianscientist and several other media)
  • Cheng, K.; Wang, X.; Yin, H. (2011) Small molecule inhibitors of the TLR3/dsRNA complex, J. Am. Chem. Soc.IF=12.113, 133, 3764-3767.
  • Wang, X.; Qu, K.; Xu, B.;  Ren, J.; Qu, X. (2011) Microwave assisted one-step green synthesis of cell-permeable multicolor photoluminescent carbon dots without surface passivation reagents, J. Mater. Chem.IF=6.626, 21, 2445-2450.
  • Wang, X.;  Qu, K., Xu, B., Ren, J., & Qu, X. (2011). Multicolor luminescent carbon nanoparticles: Synthesis, supramolecular assembly with porphyrin, intrinsic peroxidase-like catalytic activity and applications, Nano Res.IF=7.010, 4, 908-920. (This research has been featured by Life Science Weekly)
  • Wang, X.; Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X. (2011) Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe, Biosens. Bioelectron.IF=6.409, 26, 4804-4809.
  • Wang, X.; Chen, Y.; Ren, J.; Qu, X. (2011) Small interfering RNA for effective cancer therapies, Mini. Rev. Med. Chem.IF=2.903, 11, 114-124.
  • Song, Y.; Wang, X.;  Zhao, C.; Qu, K.; Ren, J.; Qu, X. (2010) Label-free colorimetric detection of single nucleotide polymorphism by using single-walled carbon nanotube intrinsic peroxidase-like activity, Chem. Eur. J.IF=5.731, 16, 3617-3621.
  • Wang, X.Geng, J.; Miyoshib,D.; Ren, J.; Sugimoto, N.; Qu, X. (2010) A rapid and sensitive "add-mix-measure" assay for multiple proteinases based on one gold nanoparticle–peptide–fluorophore conjugate, Biosens. Bioelectron.IF=6.409, 26, 743-747.
  • Wang, X.; Wang, C.; Qu, K.; Song, Y.;Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X. (2010). Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes, Adv. Funct. Mater.IF=11.805, 20, 3967-3971. (Inner cover article; This work has been highlighted by WILEY-VCH Materials Views China, the leading nanotechnology website Nanowerk and several other media)
  • Peng, Y.; Wang, X.; Xiao, Y.; Feng, L.; Zhao, C.; Ren. J.; Qu, X. (2009)  i-motif quadruplex DNA-based biosensor for distinguishing single-and multiwalled carbon nanotubes, J. Am. Chem. Soc.IF=12.113, 131, 13813-13818.
  • Wang, X.; Song, Y.; Ren, J.; Qu, X. (2009) Knocking-down cyclin A2 by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin, PLoS OneIF=3.234, 4, e6665.
  • Yu, H.; Wang, X.; Fu, M.; Ren, J.; Qu, X. (2008) Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res.IF=9.112, 36, 5695-5703.
  • Shi, Q.; Wang, X.; Ren, J. (2008) Biophysical characterization of the interaction of p21 with calmodulin: a mechanistic study, Biophys. Chem.IF=1.986, 138, 138-143.
  • Wang, X.; Ren, J.; Qu, X. (2008) Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells, Chem. Med. Chem.IF=2.968, 3, 940-945. (It is one of the most cited papers Chem. Med. Chem. published in 2008/2009)
  • Wang, X.; Ren, J.; Qu, X. (2008) Biophysical studies on the full-length human cyclin A2: protein stability and folding/unfolding thermodynamics, J. Phys. Chem. BIF=3.302, 112, 8346-8353.
  • Bao, H.; Wang, X.; Yu, H.; Fu, M.; Qu, X.; Zheng, Y.; Ren, J. (2007) Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett.IF=1.897, 436, 252-257.
  • Wang, X.; Fu, M.; Ren, J.; Qu, X. (2007) Evaluation of different culture conditions for high-level soluble expression of human cyclin A2 with pET vector in BL21 (DE3) and spectroscopic characterization of its inclusion body structure, Protein Expr. Purif.IF=1.695, 56, 27-34.

发表著作:

  • Wang, X.; Cochran, T. A.; Hutchinson, M. R.; et al., Drug Addiction, in Microglia in Health and Disease, M.-È. Tremblay and A. Sierra, Editors. 2014, Springer New York: New York, NY. 299-317. (Chapter)